Smokeless Tobacco Products (STPs)

Testing for Unique & Complicated Matrices

Enthalpy Specialty Labs offers a range of test methods for the collection and analysis of HPHCs in smokeless tobacco products (STP) including chewing tobacco (loose leaf, plug, or twist), snus, dissolvable tobacco, and snuff (moist, dry, or in packets). This includes methods that cover a range of compounds including nicotine and the FDA’s list of HPHCs.

Overview

Smokeless Tobacco Products (STPs) are modified risk tobacco products (MRTPs) that allow nicotine delivery without combustion.

Enthalpy Specialty Labs offers a range of test methods for the collection and analysis of select compounds in traditional STPs including chewing tobacco (loose leaf, plug, or twist), snus, dissolvable tobacco, and snuff (moist, dry, or in packets). These methods cover a range of compounds including nicotine and the FDA’s list of HPHCs. In addition, we can assist clients with long-term stability projects with on-site and off-site storage capabilities, flavor-marker testing, dissolution / artificial saliva, and the analysis of client generated in-vitro toxicology samples.

Other related offerings:

  • Tobacco-free nicotine pouches
  • Oral nicotine pouches
  • White pouches
  • Gum

Testing Details

Our Smokeless Tobacco Product services fulfill the requirements of:
  • Health Canada
  • FDA (USA) 2012 Abbreviated HPHC Testing
  • FDA (USA) Substantial Equivalence (SE) Testing
  • Analyses consistent with the Gothia Tek® standard developed by Swedish Match

Below is a list of the FDA recommended HPHC testing that Enthalpy Specialty Labs can offer:

HPHCs in Smokeless Tobacco
Method Description
AM-031 TSNAs in smokeless Tobacco by LC/MS-MS: NAB,NAT,NNK,NNN
AM-052 Metals by ICP/MS: Arsenic, Cadmium
AM-072 Nicotine Content in Smokeless Tobacco by GC-FID
AM-125 Benzo[a]pyrene in Smokeless Tobacco by UHPLC
AM-238 Nicotine-N-Oxide in Tobacco by LC/MS
AM-240 Carbonyls in Tobacco by UPLC-MS/MS:Formaldehyde, Acetaldehyde, Crotonaldehyde
Smokeless Tobacco Unique Testing offering
Method Description
MISC Pouch Dissolution Studies
AM-071 pH
AM-233 Water Activity in Smokeless Tobacco
TOX-011 Total Yeast/Mold Count – FDA BAM: 8ed. Ch18 Total Aerobic Plate Count – AOAC 966.23