Heated Tobacco Products

Modified Risk Tobacco Product (MRTP) Testing


Enthalpy is constantly adapting to the needs of the nicotine market. Since the onset of heated tobacco product development for tobacco harm reduction (THR), Enthalpy has been on the forefront of HNB (heat not burn) / HTP testing. Enthalpy has developed and validated a variety of HPHC methods for heated tobacco products. Below is a list of the common HPHCs Enthalpy can detect.

Testing Details

Enthalpy’s HTP product services fulfill the requirements of:
  • FDA (USA) HPHC Testing
  • FDA (USA) Premarket Tobacco Application (PMTA) Testing
  • EU-TPD Testing
HTP Aerosol HPC Testing
AM-099 Triacetin by GC/MS
AM-216 NO, NOx by Chemiluminescence
AM-245 Semi-volatiles I by GC/MS: Acetamide, Acrylamide
AM-249 Metals by ICP/MS: Arsenic, Cadmium, Chromium, Copper, Nickel, Lead
AM-253 PAHs by GC/MS: Benzo[a]pyrene, Benz[a]anthracene, Dibenz[a,h]anthracene, Pyrene
AM-257 Semi-volatiles II by GC/MS: Styrene, pyridine, quinoline, nitrobenzene
AM-262 Carbonyls by GC/MS: Acetaldehyde, Acrolein, Acetol (Hydroxyacetone), Propionaldehyde, Acetone, Crotonaldehyde, Butyraldehyde, 2-butanone (MEK), Formaldehyde
AM-265 Mercury by ICP/MS
AM-266 Furan, 2-furanmethanol (Furfuryl alcohol) by GC/MS
AM-266 Aromatic Amines by GCMS: o-Toluidine (2-methylaniline), 2,6-Dimethylaniline (2,”6-xylidene”), o-Anisidine (2-methoxyaniline), 1-Aminonaphthalene (1-naphthylamine), 2-Aminonaphthalene (2-naphthylamine), 3-Aminobiphenyl, 4-Aminobiphenyl, Benzidine (1,1′-biphenyl-4,4′-diamine)
ENT185 Primary Constituents by GC/FID : Nicotine, Menthol, Glycerin, Propylene glycol
ENT185 Carbon monoxide by CO Analyzer
ENT203 Glycidol, 3-CPD by GC/MS
ENT208 Volatiles by GC/MS: 1,3-Butadiene, Acrylonitrile, Benzene, Isoprene, Toluene, Propylene oxide, Ethylene oxide, Vinyl chloride
ENT306 Phenols by HPLC/FD: Catechol, Phenol, Hydroquinone, Resorcinol, o-Cresol, m&p-cresol
ENT307 Ammonia by HPLC/IC
ENT335 Hydrogen cyanide by HPLC/IC